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Faculty of Medicine
Document Details
Document Type
:
Article In Journal
Document Title
:
Skin-derived precursor cells enhance peripheral nerve regeneration following chronic denervation
Skin-derived precursor cells enhance peripheral nerve regeneration following chronic denervation
Subject
:
Neurosurgery
Document Language
:
English
Abstract
:
While peripheral nerves demonstrate the capacity for axonal regeneration, outcome following injury remains relatively poor, especially following prolonged denervation. Since axon-deprived Schwann cells (SCs) in the distal nerve progressively lose their ability to support axonal growth, we took the approach of using skin-derived precursor cells (SKPs) as an accessible source of replacement SCs that could be transplanted into chronically denervated peripheral nerve. In this study, we employed a delayed cross-reinnervation paradigm to assess regeneration of common peroneal nerve axons into the chronically denervated rodent tibial nerve following delivery of SKP-derived SC (SKP-SCs). SKP-SC treated animals exhibited superior axonal regeneration to media controls, with significantly higher counts of regenerated motorneurons and histological recovery similar to that of immediately repaired nerve. Improved axonal regeneration correlated with superior muscle reinnervation, as measured by compound muscle action potentials and wet muscle weights. We therefore conclude that SKPs represent an easily accessible, autologous source of stem cell-derived Schwann cells that show promise in improving regeneration through chronically injured nerves
ISSN
:
0014-4886
Journal Name
:
Experimental Neurology
Volume
:
223
Issue Number
:
1
Publishing Year
:
1431 AH
2010 AD
Article Type
:
Article
Added Date
:
Thursday, April 7, 2011
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
بسام عداس
Addas, Bassam
Researcher
Doctorate
Files
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Description
29585.pdf
pdf
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