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Document Details
Document Type
:
Thesis
Document Title
:
New Synthesis of Thiopurine and Thioumazine Derivatives and study of their Biological Activities.
تحضير بعض مشتقات الثيوويوراسيل المندمجة الجديدة ودراسة التأثير البيولوجي لها
Subject
:
New Synthesis of Thiopurine and Thioumazine Derivatives and study of their Biological Activities.
Document Language
:
Arabic
Abstract
:
Several 1-methyl-6-substitued -2-thiopyrimido[4,5-d]pyrimidines-4-one,ethyl-7-amino-5-aryl-1-methyl-4-oxo-2-thio-pyrido[2,3-d]pyrimi-dine- 6-carboxylate were synthesized by treatment of 6-amino-1-methyl-2-thiouracil with primary amines and formaldehyde 40%, and with ethyl 3-arylcyano olefins-3-carboxylate respectively. 7-Hydroxy-3-methyl-8-substituted-2-thioxanthines were synthesized by the treatment of 6-amino-1-methyl-5-nitroso-2-thiouracil with benzylidine anilines. Synthesis of 8-aryl-3-methyl-2-thioxanthines was achieved from 6-amino-1-methyl-2-thiouracil. On the other hand, the treatment of 5-nitroso-, or 5-amino-2-thiouracil derivatives with phenacyl bromides in presence of ZnCl2 afforded 7-aryl- and 6-aryl-2-thiolumazines respectively. The antiviral and antimicrobial studies were performed for the . All the new compounds were performed by elemental and spectral analyses and the antimicrobial analysis was carried out for some of them.
Supervisor
:
Dr.
Thesis Type
:
Doctorate Thesis
Publishing Year
:
1429 AH
2008 AD
Added Date
:
Saturday, May 9, 2009
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
فاطمة عبدالعزيز عقيلي
Agili, Fatimah Abdulaziz
Researcher
Doctorate
Files
File Name
Type
Description
19941.pdf
pdf
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